BioStat LLC, Order Celox, FoxSeal and SilvaPro BioStat LLC - 844-246-7828
Biostat LLC at Facebook
Saves Time. Saves Blood. Saves Lives.

You don't always have three minutes because you don't know what's coming next.

Celox™RAPID
The fastest hemostatic gauze treatment available(1) Celox™RAPID Ribbon
The first compact carry minimal compression time
gauze for narrow entry wounds.

Celox™RAPID

Bandage dimensions 3"x5'

P/N #FG08839011

 

Celox™RAPID Ribbon

Bandage dimensions 1"x5'

P/N #FG08839041

 

 
 

  Click hereto contact  us for moreinformation

RAPID PACKING    
Celox™ RAPID 5’Z-Fold packs faster than other 12’competitive gauzes. RAPID has
demonstrated faster packing in both In Vitro and  Field Testing. On average, the time taken with Celox™ RAPID  was half of the time with either of the other two products(1) (Combat Gauze™ and ChitoGauze™)

 

RAPID COMPRESSION    
Celox™ RAPID speeds up compression time. This is demonstrable based on in vivo results that are similar or better after one minute than results after three minutes compression for ChitoGauze™ or Quikclot Combat Gauze™ in previous studies. Based on independent study, Celox™ Rapid can eliminate the compression step entirely after packing. (2)

REDUCED BLOOD LOSS   
Celox™ RAPID demonstrated
decreased secondary blood loss in comparison to Combat Gauze (4).

 

STABILITY IN EVACUATION    
Celox™ RAPID maintains its volume and adhesion to wet tissue during use, helping it to stay in place during patient transport and maintain hemostasis during transit. In comparative testing against Chitogauze™ and Combat Gauze, Celox™ RAPID demonstrated significantly stronger adhesion after treatment at time intervals of one minute, three minutes and twenty minutes. Because Celox™ RAPID sticks to wet tissue, its use results in performance benefits including hemostasis speed, reduced blood loss and safer transit of severely wounded patients. (3)

 

(1) Reduced Application Time with a Rapid Packing Gauze Hemostat

Andrew Hoggarth, Craig Hardy, Guy Eason, Chris Marsden (Medtrade Products Ltd, Crewe, UK)

(2) Testing a new gauze hemostat with reduced treatment time Hoggarth A1, Hardy C1, Millner R2, Lyon A1 (1: Medtrade Products Ltd, UK, 2: Blackpool Victoria Hospital, UK )

(3) Mechanism of action of rapid-action gauze hemostat  Authors: Andrew Hoggarth, Craig Hardy, Guy Eason, Andrew Lyon, Chris Marsden (Medtrade Products Ltd, Crewe, UK)

(4)  Chitosan based advanced hemostatic dressing is associated with decreased blood loss in a swine uncontrolled hemorrhage model Corrected Proof, 15 March 2013 Nicholas R. Kunio, Gordon M. Riha, Katherine M. Watson, Jerome A. Differding, Martin A. Schreiber, Jennifer M. Watters  10.1016/j.amjsurg.2013.01.014  The American Journal of Surgery

Saves Time. Saves Blood. Saves Lives.

When faced with life-threatening hemorrhage and under extreme conditions, seconds

count…

In side by side independent evaluation of the efficacy of two dissimilar commercially available hemostatic gauze agents under conditions that best replicate the physiological responses following penetrating traumas to major blood vessels and vital organ systems, the chitosan-based Celox™ RAPID Gauze reliably compressed lethal arterial hemorrhage in a standardized swine model within one minute. Correspondingly, the kaolin-based QuikClot® Combat Gauze™ achieved similar results with three minutes of compression time utilizing six

times more product.

Care Under Threat
     As the occurrences of violent and brutal acts escalates, so too have the demands to provide care under increasingly chaotic and life threatening conditions. Celox™ RAPID defines Tactical Hemostasis and bridges the significant capability gap between emerging tactics and the current standard of treatment for hemorrhage control.

 

Medical Force Multiplier
     The medical and downstream tactical implications of active shooter, officer down or mass-casualty situations demand high-speed, easy-to-use ‘Tactical Hemostatic’ products.

    With Rapid Packing and Minimal Compression, Celox™ RAPID can reduce hemostasis to a minute or less expanding the first responders capabilities  to care for other wounds or casualties.

     A 5’ Celox™ RAPID  packs faster, requires minimal post-application compression, reduces blood loss, and provides  greater stability in evacuation compared to competitive products.

     Independent in vivo testing showed 100 % success in achieving hemostasis and reduced blood loss compared to other treatments*.

     Celox™ RAPID has also been tested in a model of casualty evacuation, achieving 100 % successful transport without re-bleeding*.

* RAPID Gauze could be rapidly applied on the wound on average within half the time of the predicate devices. Has been proven in controlled trials to stop major arterial bleeding by coagulating the blood within 1 minute, reducing blood loss.

 

Medical Force
Multiplier
Celox™  RAPID
can eliminate the compression step entirely after
packing.

*Combat Gauze™ is a registered TM of Z-Medica

 

Chito-R™

     The positively charged activated chitosan in Chito-R™ rapidly absorbs blood.  This process creates a robust gel plug over the bleeding source independent of the body’s intrinsic clotting cascade. The activated chitosan in Chito-R is a compound of glucosamine and N-acetyl glucosamine, naturally occurring basic sugars.

     Celox™ RAPID with Chito-R™, addressing the significant capability gap of the current standard of treatment for hemorrhage control. Celox™ RAPID can eliminate the compression step entirely after packing.

 

Celox™ RAPID is suitable for:

 

• Severe high pressure bleeding

• Arterial and venous bleeding

• Bullet, blast, knife and shrapnel wounds

• Wound packing

• Applying through strong blood flows

• Application to all bleeding wounds

Stops Bleeding. Saves Lives. The 
 '3-Minute' 
 Gauzes…

Celox™ Gauze had the highest observed survival rate with 90% of the animals surviving, while Combat Gauze™ had a 60% survival rate.

ONR 2012(1) Standard Swine Model of Uncontrolled Hemorrhage

Celox™ Gauze, designed and intended for the control of severe bleeding, offers numerous Clinical, Tactical, and Economical advantages over other ‘3-Minute’ hemostatic dressings such as Combat Gauze™, Combat Gauze™ XL, and ChitoGauze™.

CLINICAL

     When placed directly into a bleeding wound and subjected to pressure Celox™ Gauze absorbs blood and forms a muco-adhesive gel that seals the wound to stop the flow of blood.

     In a recent Navy Study(1), Celox™ Gauze clearly and consistently outperformed competitors in several areas relevant to a Combat or Tactical Medic. They include: Immediate Hemostasis (defined as a 3 minute compression period), Post-Application Blood Loss, and most notably, Survival.

     These features present initial and ‘downstream’ benefits for both the casualty and the medic making Celox™ Gauze the preferred choice of the ‘3-Minute’ Gauzes.

(1) Rall JM et al. Comparison of Novel Hemostatic gauzes to Quikclot Combat Gauze in a standardized swine model of uncontrollable hemorrhage.

ECONOMICAL

     Celox™ Gauze  does not double in price for double the volume.

For massive traumatic wound packing, Celox™ Gauze 10’ Z-Fold can provide the clinically desired additional volume WITHOUT the double Extra Large product price***.  A unit of Celox™ 10’ Gauze is capable of packing more than twice the wound volume of some of its competitors.

Celox™ Gauze is a high performance hemostatic gauze that offers clinical, tactical, and economical advantages over competitive '3-Minute' Gauzes.

Celox™ utilizes chitosan, a compound of glucosamine, a sugar that is normally found in the body.

Immediate
Hemostasis

Dressing Length
(inches)

Immediate hemostasis (no visible bleeding from the wound during the first three minutes after compression) (1)

Celox™
does NOT use or
release non-degrading, procoagulant minerals such as kaolin, which will remain in the body indefinitely unless completely removed.

ARE YOU CARRYING THE BEST?

10 Minute

Blood Loss

Celox™ 5’ Gauze is nearly 60% shorter in length compared to  12’ Combat Gauze, 12’ Combat Gauze™ XL, and 12’ ChitoGauze™. (1)

TACTICAL

     You don’t always get to choose your Phase of Care.

     ‘3 Minutes’ of direct pressure begins after dressing application ends. ‘Packs faster’ can be the difference between your safety and tactical medical superiority for your casualty. Celox™ 5’ Gauze is nearly 60% shorter in length compared to competitive products while filling the same size wound. The shorter gauze allows significantly faster wound packing.  Celox™ 5’ Z-Fold Gauze is intuitive, easy to handle, and reduces application time during all phases of care.

 

90%

SURVIVAL RATE

Celox™ Gauze demonstrated higher rates of Survival when compared to the current standard of care, Combat Gauze. (1)

70%

60%

CHITOGauZE

SURVIVAL RATE

COMBATGauZE

SURVIVAL RATE

QuikClot Combat Gauze™ treated-animals shed 4.5-fold more blood than Celox™ Gauze (10.8 ml/kg vs. 2.4 ml/kg) during the Platinum Ten Minutes. (1)

(1) Rall JM et al. Comparison of Novel Hemostatic gauzes to Quikclot Combat Gauze in a standardized swine model of uncontrollable hemorrhage.

Stops Bleeding. Saves Lives.
Celox™-A

ACCELERATED
• Delivers 6g directly

• Promotes Rapid Coagulation

• Works in hypothermic conditions

• Clots heparnized blood

 

Celox™-A
The first high-speed hemostatic delivery system for gunshot, blast, and stab wounds.

     The first high-speed hemostatic delivery system for gunshot, blast, or stab wounds. The applicator was designed to give the caregiver a simple and effective tool to apply Celox™ to the source of severely bleeding wounds. The Celox-A™ Applicator has been integrated into thousands of IFAKs to create a comprehensive ‘bleeder’ kit for shrapnel, IED, gunshot, and knife wounds.

     When placed directly into a bleeding wound and subjected to pressure CELOX™ absorbs blood and forms an adhesive gel that seals the wound to stop the flow of blood. Celox™ has repeatedly and reliably demonstrated the ability to stop arterial bleeding in independent US Navy severe bleeding tests(1).

     In a published 2011 comparison(2), Celox™-A outperformed Combat Gauze in a lethal penetrating trauma model in both Initial Hemostasis and Survival.

(1) Kozen B et al. An alternative hemostatic dressing: comparison of CELOX, Hemcon and Quikclot.  J Acad Emerg Med 2008: 15; 74-81.   January 2008, Vol 15 No 1. 
(2) Littlejohn LF et al.  Acad Emerg Med 2011: 18; 340-350.

Stops Bleeding. Saves Lives.
Celox™ Granules

     Celox™ can stop even potentially lethal bleeding fast. It is easy to use (just pour, pack and apply pressure), very safe (tested to class 3 CE Mark standards) and extremely effective.

     When mixed with blood, Celox™ forms a robust gel-like clot in 30 seconds. When mixed with blood, Celox™ forms a robust gel-like clot in 30 seconds.It works independently of the body’s normal clotting processes. Celox’s™ clotting ability has been proven to work in the cold (hypothermia) or in the presence of common anti-coagulants such as warfarin. It generates no heat and will not burn the casualty or care giver.

     In pre-clinical tests by the US Navy, Celox™ was the only product to give 100% survival. It gave a strong stable MAP (mean arterial blood pressure) and was also the only product to give robust clotting with no rebleeding*.

     Celox’s™ safety has been tested to the intense class 3 CE mark standards. Celox™ is made with chitosan. Chitosan is made up of compounds of glucosamine, a sugar that is normally found in the body.

     Celox™ does NOT use non-degrading procoagulant minerals or nano particles such as smectite or kaolin, which will remain in the body indefinitely unless completely removed.

 

DYNAMIC APPLICATIONS

• Granular presentation provides for the most diverse set of uses

• Works in hypothermic conditions

• FDA cleared to work on anti-coagulated blood

• No chemical exothermic reaction

Safety

     The chitosan in Celox™ is a specific high quality grade selected for medical use from a shellfish source.  Chitosan is made up of glucosamine and N-acetyl glucosamine, which are naturally occurring sugars in the body.

     The chitosan in Celox™  is free from animal proteins that would be the cause of any allergic response.  It has been tested for allergenic reaction on humans with a known fish or shrimp hypersensitivity and none of the subjects showed any skin reaction to the chitosan(1).

     Our products have been through extensive safety and biocompatibility testing to the ISO 10993 standards, the FDA device requirements, and the most stringent class of European Medical Device regulations.

     Because Celox™  works independently of the body’s clotting cascade it only works where it directly

 touches the blood.  It does not set off any thrombotic chain reaction elsewhere that could lead to increased risk of blood clots.

     The glucosamine and N-acetyl glucosamine sugars in the chitosan are naturally occurring materials and the body has known metabolic pathways to break down and excrete them(2). This is unlike other hemostats that can leave mineral residuals in the body(3)(4).

     Celox™ has had thousands of successful uses since first launched in 2006 with no adverse events reported.

 

 

 

 

 

 

 

 

(1) Medtrade data on file.

(2) Int. J. Biol. Macromol., 1992, Vol 14 August

(3) Moeng SF, Moar JJ. Quikclot masquerading as Glazer shot: a new forensic pathology artefact?  Am J Forensic Med Pathol 2012; 33(3): 238-241.

(4) Hoggarth A, Alden M.  Evaluation of the use of hemostatic agents and the residual particles left in the wound.  Presented at Symposium for Advanced Wound Care, Anaheim, 2010.

BioStat LLC - 844-246-7828

844 BIO STAT

844.246.7828

 

 

118 East Jefferson Street

Suite 300

Orlando, Florida 32801

407-252-6758

Proud sponsor of Wounded Warrior Project
BioStat LLC, Order Celox, FoxSeal and SilvaPro